Laboratory of Molecular Structure Characterization
The multidisciplinary laboratory addresses medical and biotechnological problems through the application of metabolomic and metallomic approaches, encompassing both fundamental and applied research. The laboratory is primarily organized around four core sections: microbiology, mass spectrometry, nuclear magnetic resonance (NMR), and electron microscopy. Through joint grant projects, economic contracts, or the REQUEST application, our staff provides support for research in collaborating Czech and foreign laboratories. Our primary application areas include infectious metallomics and diagnostics (the study of the molecular basis of diseases of the respiratory system, urinary tract, and central nervous system), metabolomic research of civilization diseases by NMR techniques (metabolic disorders), microbial physiology and biotechnology (the study of secondary metabolism in microbes and the biodegradation of drugs).
Infection metallomics
Laboratory concept
Laboratory central analytical concept, named infection metallomics, exploits host-microbial consortia interactions moderated with antimicrobial therapies in the lung, central nervous system, and urogenital tract infections. The approach is based on isotopic data filtering and CycloBranch application. In the targeted and untargeted ways, the application quantifies the metal-containing interacting partners on the pathogen-host interface.
Our analytical tools
Combination to characterize the molecular structure
01.
MS
Mass spectrometry
02.
NMR
Nuclear magnetic resonance
03.
EM
Electron microscopy
04.
MicroBio
Anchoring the three tools via molecular and microbiology
Bridge to public
Media & PR
Our activities are aimed not only to peer reviewed papers and conferences. Providing information about state-of-the-art research to the public is another key acitivity of our team.
Skillful team of experts
Our team consists of four main groups – NMR, EM, MBIO and MS. The whole team incorporates both skilled experts as well as post doctoral, doctoral and undergraduate students. The success of our lab is based on tight cooperation with our technical and supporting staff.
Are you interested in cooperation? Our lab offers a number of vacancies for students and your professionals. Let’s go ahead and become a passionate scientist with us!
