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Laboratory central analytical concept, named infection metallomics, exploits host-microbial consortia interactions moderated with antimicrobial therapies in the lung, central nervous system, and urogenital tract infections. The approach is based on isotopic data filtering and CycloBranch application. In the targeted and untargeted ways, the application quantifies the metal-containing interacting partners on the pathogen-host interface. The nuclear magnetic resonance group operates a four-channel 700 MHz instrument with a cryo-probe dedicated to small molecule and protein analysis. An analogous 600 MHz NMR instrument running in an HPLC-NMR configuration is used in metabolomics projects (murine lipoatrophy and diabetes mellitus). It can also be linked online to a Q-TOF mass spectrometer. The microscopy group runs multiple electron microscopes and optical microscopy equipment. An FEI NanoSEM 450 scanning electron microscope was equipped with a CBS detector for high-resolution imaging of nonconductive samples and an EDAX Octane Plus detector for EDS analysis and elemental mapping.
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